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1741 John LOCKE Essay Concerning Human Understanding Philosophy Tabula Rasa 2v I have always thought the actions of men the best interpreters of their thoughts. John Locke After studying medicine under the teaching of Thomas Sydenham, John Locke began his journey of philosophical thinking that would develop into his most famous written work. An Essay Concerning Human Understanding, is one of the most important books on the development and cultivation of human understanding and knowledge. It is in this work that Locke first describes the idea of blank slate of the mind or tabula rasa. Locke s Essay is known to have directly influenced famous philosophers such as David Hume and George Berkeley. This rare 1741 two-volume edition was published in London and features a portrait of Locke.